The Mechanism of Action of the Activated Nitrogen-Containing Metabolites in the Respiratory Tract. Proinflammatory Effect (Part 2)

Abstract

The review of literature presents modern data about antibacterial and antiviral effect of nitrogen monoxide. Bactericidal action of nitric monoxide in the phagosome, involvement of nitrogen monoxide in the development of influenza infection are considered in detail. The value of activity of inducible isoform of nitrogen oxide synthetase in infectious di­seases caused by various pathogens is presented. The participation of alveolar macrophages in the formation of peroxynitrite, the effect of nitric monoxide on the drainage function of the respiratory tract, bronchodilatory and bronchoprotective action of nitrogen monoxide are shown.

Keywords

• activated nitrogen-containing metabolites
• lungs
• proinflammatory effect