Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Takafumi Suzuki; Shiori Seki; Keiichiro Hiramoto; Eriko Naganuma; Eri H. Kobayashi; Ayaka Yamaoka; Liam Baird; Nobuyuki Takahashi; Hiroshi Sato; Masayuki Yamamoto

doi:10.1038/ncomms14577

Nature Communications (Feb 2017)

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Takafumi Suzuki,
Shiori Seki,
Keiichiro Hiramoto,
Eriko Naganuma,
Eri H. Kobayashi,
Ayaka Yamaoka,
Liam Baird,
Nobuyuki Takahashi,
Hiroshi Sato,
Masayuki Yamamoto

Affiliations

Takafumi Suzuki: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Shiori Seki: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Keiichiro Hiramoto: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Eriko Naganuma: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Eri H. Kobayashi: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Ayaka Yamaoka: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Liam Baird: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Nobuyuki Takahashi: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences
Hiroshi Sato: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences
Masayuki Yamamoto: Department of Medical Biochemistry, Tohoku University Graduate School of Medicine

DOI: https://doi.org/10.1038/ncomms14577
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficking and water permeability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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