Superoxide Anions Inhibit Intracellular Calcium Response in Porcine Airway Smooth Muscle Cells

Abstract

Background Superoxide anions (O2 −) have multiple effects on pulmonary parenchyma altering cell proliferation, cellular metabolism, and airway smooth muscle (ASM) contraction. Intracellular calcium ([Ca2+]i) concentration plays a significant role in the regulation of ASM contraction, relaxation, proliferation, and gene expression.

Keywords

• superoxide
• airway smooth muscle cell
• intracellular calcium
• superoxide dismutase
• oxidative
• lung illnesses