The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma

Su Yin Lim; Elena Shklovskaya; Jenny H. Lee; Bernadette Pedersen; Ashleigh Stewart; Zizhen Ming; Mal Irvine; Brindha Shivalingam; Robyn P. M. Saw; Alexander M. Menzies; Matteo S. Carlino; Richard A. Scolyer; Georgina V. Long; Helen Rizos

doi:10.1038/s41467-023-36979-y

Nature Communications (Mar 2023)

The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma

Su Yin Lim,
Elena Shklovskaya,
Jenny H. Lee,
Bernadette Pedersen,
Ashleigh Stewart,
Zizhen Ming,
Mal Irvine,
Brindha Shivalingam,
Robyn P. M. Saw,
Alexander M. Menzies,
Matteo S. Carlino,
Richard A. Scolyer,
Georgina V. Long,
Helen Rizos

Affiliations

Su Yin Lim: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
Elena Shklovskaya: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
Jenny H. Lee: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
Bernadette Pedersen: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
Ashleigh Stewart: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
Zizhen Ming: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
Mal Irvine: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
Brindha Shivalingam: Melanoma Institute Australia, The University of Sydney
Robyn P. M. Saw: Melanoma Institute Australia, The University of Sydney
Alexander M. Menzies: Melanoma Institute Australia, The University of Sydney
Matteo S. Carlino: Melanoma Institute Australia, The University of Sydney
Richard A. Scolyer: Melanoma Institute Australia, The University of Sydney
Georgina V. Long: Melanoma Institute Australia, The University of Sydney
Helen Rizos: Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University

DOI: https://doi.org/10.1038/s41467-023-36979-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 18

Abstract

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Immunotherapy resistance is common among melanoma patients. Here, the authors identify three resistance mechanism subtypes across tumor-derived cell lines and matched samples and highlight antigen presentation disruption as a key mediator of resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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