Posttransplant lymphoproliferative disorder in a kidney transplant recipient: a case of Epstein-Barr virus-positive primary central nervous system lymphoma
Hassam Ali,
Syed Hamza Bin Waqar,
Marwan Majeed,
Alina Sehar,
Aqsa Mumtaz
Affiliations
Hassam Ali
Department of Internal Medicine, East Carolina University/Vidant Medical Center, Greenville, NC, USA
Syed Hamza Bin Waqar
Department of Internal Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY, USA
Marwan Majeed
Department of Pathology, East Carolina University/Vidant Medical Center, Greenville, NC, USA
Alina Sehar
Department of Internal Medicine, United Medical and Dental College, Karachi, Pakistan
Aqsa Mumtaz
Department of Internal Medicine, King Edward Medical University, Lahore, Pakistan
Posttransplant lymphoproliferative disorders (PTLDs) are potentially life-threatening complications of chronic immunosuppression in patients who receive solid organ transplants or allogeneic hematopoietic cell transplantation. Most PTLD cases are associated with Epstein-Barr virus (EBV) serology, and their incidence is typically higher in the first year of transplantation. Isolated EBV-positive diffuse large-cell B-cell lymphoma in the renal transplant setting has rarely been reported. Isolated EBV-positive primary central nervous system lymphoma (PCNSL) is rare, even in renal transplant patients with chronic immunosuppression. We report a case of frontal lobe EBV-positive PCNSL in a renal transplant patient who presented with left-sided weakness and was later treated with a consolidated chemotherapeutic regimen without concurrent radiotherapy.
