Nature Communications (Dec 2020)
Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
- Chong Wang,
- Luyao Zhang,
- Liangru Ke,
- Weiyue Ding,
- Sizun Jiang,
- Difei Li,
- Yohei Narita,
- Isabella Hou,
- Jun Liang,
- Shijun Li,
- Haipeng Xiao,
- Eva Gottwein,
- Kenneth M. Kaye,
- Mingxiang Teng,
- Bo Zhao
Affiliations
- Chong Wang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Luyao Zhang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Liangru Ke
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Weiyue Ding
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Sizun Jiang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Difei Li
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Yohei Narita
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Isabella Hou
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Jun Liang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Shijun Li
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Haipeng Xiao
- Dept. of Medicine, The First Affiliated Hospital, Sun Yat-Sen University
- Eva Gottwein
- Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University
- Kenneth M. Kaye
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Mingxiang Teng
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute
- Bo Zhao
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-20136-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Primary effusion lymphoma (PEL) has a very poor prognosis. Here, the authors perform H3K27ac HiChIP in PEL cells and generate the PEL enhancer connectome, linking enhancers and promoters in PEL, as well as super-enhancers to dependency factors.
