A novel mixture of curcumin paste and prednisolone for treating oral lichen planus: A case controlled comparative study

Abstract

Background and Aims: This study was done to evaluate the clinical efficacy as a topical drug of a novel mixture of prednisolone and curcumin in oral lichen planus. Methods: Our study included 60 cases of symptomatic oral lichen planus. Patients were divided into two groups of 30 each. Group 1 received first mode of therapy of topical curenext gel. Group 2 received second mode of therapy of novel mixture of curenext gel and prednisolone. They were reviewed after 10 days and 20 days. Findings: Novel mixture effectively reduced the reticulation, erosion and pain and these differences were significant when compared with first mode of therapy. Conclusion: We would recommend the use of novel mixture for treatment of any case of symptomatic oral lichen planus than using curenext alone. Practical Implications: Topical curcumin alone is not effective against oral lichen planus. If this is mixed with a steroid, the mixture could give the benefits of steroid and curcumin together and hence appear to be more effective.

Keywords

• curcumin
• novel mixture
• oral lichen planus
• prednisolone
• topical application