Nature Communications (May 2016)

14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila

  • Thao Phuong Le,
  • Linh Thuong Vuong,
  • Ah-Ram Kim,
  • Ya-Chieh Hsu,
  • Kwang-Wook Choi

DOI
https://doi.org/10.1038/ncomms11501
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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14-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ development.