Nature Communications (Mar 2019)

Unusual substrate and halide versatility of phenolic halogenase PltM

  • Shogo Mori,
  • Allan H. Pang,
  • Nishad Thamban Chandrika,
  • Sylvie Garneau-Tsodikova,
  • Oleg V. Tsodikov

DOI
https://doi.org/10.1038/s41467-019-09215-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Halogenase enzymes are of interest as halogenating tools for organic synthesis. Here the authors show that the bacterial FAD-dependent phenolic halogenase PltM chlorinates, brominates and iodinates a variety of substrates and reveal the structural basis for its substrate versatility and provide insights into the FAD recycling mechanism of PltM.