Journal of Hematology & Oncology (Nov 2022)

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

  • Xinyang Zhong,
  • Xuefeng He,
  • Yaxian Wang,
  • Zijuan Hu,
  • Huixia Huang,
  • Senlin Zhao,
  • Ping Wei,
  • Dawei Li

DOI
https://doi.org/10.1186/s13045-022-01358-5
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 29

Abstract

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Abstract Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation and drug resistance. Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy.

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