F1000Research (Aug 2017)

BAT: Bisulfite Analysis Toolkit [version 1; referees: 2 approved]

  • Helene Kretzmer,
  • Christian Otto,
  • Steve Hoffmann

DOI
https://doi.org/10.12688/f1000research.12302.1
Journal volume & issue
Vol. 6

Abstract

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Here, we present BAT, a modular bisulfite analysis toolkit, that facilitates the analysis of bisulfite sequencing data. It covers the essential analysis steps of read alignment, quality control, extraction of methylation information, and calling of differentially methylated regions, as well as biologically relevant downstream analyses, such as data integration with gene expression, histone modification data, or transcription factor binding site annotation.

Keywords