Nature Communications (Aug 2022)
Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly
- Karin Taş,
- Beatrice Dalla Volta,
- Christina Lindner,
- Omar El Bounkari,
- Kathleen Hille,
- Yuan Tian,
- Xènia Puig-Bosch,
- Markus Ballmann,
- Simon Hornung,
- Martin Ortner,
- Sophia Prem,
- Laura Meier,
- Gerhard Rammes,
- Martin Haslbeck,
- Christian Weber,
- Remco T. A. Megens,
- Jürgen Bernhagen,
- Aphrodite Kapurniotu
Affiliations
- Karin Taş
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- Beatrice Dalla Volta
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- Christina Lindner
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- Omar El Bounkari
- Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilian-University (LMU)
- Kathleen Hille
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- Yuan Tian
- Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilian-University (LMU)
- Xènia Puig-Bosch
- Department of Anesthesiology and Intensive Care, Technical University of Munich/Klinikum Rechts der Isar
- Markus Ballmann
- Department of Anesthesiology and Intensive Care, Technical University of Munich/Klinikum Rechts der Isar
- Simon Hornung
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- Martin Ortner
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- Sophia Prem
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- Laura Meier
- Center for Protein Assemblies, Department of Chemistry, Technical University of Munich
- Gerhard Rammes
- Department of Anesthesiology and Intensive Care, Technical University of Munich/Klinikum Rechts der Isar
- Martin Haslbeck
- Center for Protein Assemblies, Department of Chemistry, Technical University of Munich
- Christian Weber
- Institute for Cardiovascular Prevention, Klinikum der Universität München, Ludwig-Maximilian-University Munich (LMU)
- Remco T. A. Megens
- Institute for Cardiovascular Prevention, Klinikum der Universität München, Ludwig-Maximilian-University Munich (LMU)
- Jürgen Bernhagen
- Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilian-University (LMU)
- Aphrodite Kapurniotu
- Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM)
- DOI
- https://doi.org/10.1038/s41467-022-32688-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Amyloid self-assembly is linked to type 2 diabetes and Alzheimer’s disease. Here the authors designed constrained peptides which are nanomolar amyloid inhibitors of the key polypeptides IAPP and Aβ42 and act via supramolecular nanofiber co-assembly.
