Nature Communications (Nov 2022)

A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes

  • Xi Wu,
  • Fei Shen,
  • Guanglong Jiang,
  • Gloria Xue,
  • Santosh Philips,
  • Laura Gardner,
  • Geneva Cunningham,
  • Casey Bales,
  • Erica Cantor,
  • Bryan Paul Schneider

DOI
https://doi.org/10.1038/s41467-022-34917-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Germline variants may pre-dispose patients to an increased risk of developing anthracycline-induced cardiotoxicity. This report provides insights into the mechanism by which a common genetic variant, rs28714259, may confer an increased risk of cardiac damage.