Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice

Wenjing Liao; Libo Zhou; Xiaolong Zhao; Lijuan Song; Yingshen Lu; Nanshan Zhong; Pingchang Yang; Baoqing Sun; Xiaowen Zhang

doi:10.1038/s41598-017-07471-7

Scientific Reports (Aug 2017)

Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice

Wenjing Liao,
Libo Zhou,
Xiaolong Zhao,
Lijuan Song,
Yingshen Lu,
Nanshan Zhong,
Pingchang Yang,
Baoqing Sun,
Xiaowen Zhang

Affiliations

Wenjing Liao: State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery
Libo Zhou: State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery
Xiaolong Zhao: State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery
Lijuan Song: State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery
Yingshen Lu: State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery
Nanshan Zhong: Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University
Pingchang Yang: State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery
Baoqing Sun: Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University
Xiaowen Zhang: State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery

DOI: https://doi.org/10.1038/s41598-017-07471-7
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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