Acute myeloid leukemia patients’ clinical response to idasanutlin (RG7388) is associated with pre-treatment MDM2 protein expression in leukemic blasts

• Bernhard Reis,
• Lori Jukofsky,
• Gong Chen,
• Giovanni Martinelli,
• Hua Zhong,
• W. Venus So,
• Michael J. Dickinson,
• Mark Drummond,
• Sarit Assouline,
• Maneja Hashemyan,
• Michel Theron,
• Steven Blotner,
• Je-Hwan Lee,
• Margaret Kasner,
• Sung-Soo Yoon,
• Ruediger Rueger,
• Karen Seiter,
• Steven A. Middleton,
• Kevin R. Kelly,
• Norbert Vey,
• Karen Yee,
• Gwen Nichols,
• Lin-Chi Chen,
• William E. Pierceall

Affiliations

Bernhard Reis

Roche Innovation Center Basel, Roche Pharma Research and Early Development, Switzerland

Lori Jukofsky

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

Gong Chen

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

Giovanni Martinelli

Seragnoli Institute of Hematology, Bologna University School of Medicine, Italy

Hua Zhong

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

W. Venus So

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

Michael J. Dickinson

Department of Haematology, Peter MacCallum Cancer Center, Melbourne, VIC, Australia

Mark Drummond

Beatson West of Scotland Cancer Center, Gartnavel General Hospital, Glasgow, United Kingdom

Sarit Assouline

Division of Hematology, Jewish General Hospital, McGill University, Montreal, QC, Canada

Maneja Hashemyan

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

Michel Theron

Roche Innovation Center Basel, Roche Pharma Research and Early Development, Switzerland

Steven Blotner

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

Je-Hwan Lee

Department of Hematology, Asian Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

Margaret Kasner

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA

Sung-Soo Yoon

Department of Internal Medicine, Seoul National University School of Medicine, Seoul, South Korea

Ruediger Rueger

Roche Innovation Center Penzberg, Roche Pharma Research and Early Development, Germany

Karen Seiter

New York Medical College, Valhalla, NY, USA

Steven A. Middleton

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

Kevin R. Kelly

University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA

Norbert Vey

Hematology, Institut Paoli Calmettes, Marseilles, France

Karen Yee

Princess Margaret Hospital, Toronto, ON, Canada

Gwen Nichols

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

Lin-Chi Chen

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA

William E. Pierceall

Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA