Nature Communications (Aug 2019)

Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening

  • Alexandre Mayran,
  • Kevin Sochodolsky,
  • Konstantin Khetchoumian,
  • Juliette Harris,
  • Yves Gauthier,
  • Amandine Bemmo,
  • Aurelio Balsalobre,
  • Jacques Drouin

DOI
https://doi.org/10.1038/s41467-019-11791-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin opening requires Tpit.