The prevalence of JC and BK viruses among prostate cancer patients in Al-Najaf Al-Ashraf province

Abstract

A total of 74 clinical samples Formalin-Fixed Paraffin-Embedded (FFPE) were collected from patients diagnosed with prostate cancer (PCa) aged between 41 and 90 years and these samples were obtained from patients treated at notable medical institutions like Al-Sadr Medical City and leading clinical laboratories in Al-Najaf City, Iraq, during the period of January to December 2023. Prostate cancer is considered a common malignant tumor in males, and studies are still investigating the possible relationship of the appearance of this disease with other factors, including viral infections, which were investigated in the current study in search of possible links between the presence of human BK oncolytic viruses (BKV). The JC (JCV) and the emergence of this disease. The current study indicated the potential role of the JCV virus in provoking prostatitis, which may lead to the emergence and development of prostate cancer in males compared to males who do not suffer from viral infection. The present study showed the absence of BKV virus DNA in prostate cancer tissue samples compared to the presence of JCV virus DNA, as the percentage of positive samples reached (11, 14.864%) compared to negative samples (63, 85.135%).