EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

Wendy Béguelin; Martín A. Rivas; María T. Calvo Fernández; Matt Teater; Alberto Purwada; David Redmond; Hao Shen; Matt F. Challman; Olivier Elemento; Ankur Singh; Ari M. Melnick

doi:10.1038/s41467-017-01029-x

Nature Communications (Oct 2017)

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

Wendy Béguelin,
Martín A. Rivas,
María T. Calvo Fernández,
Matt Teater,
Alberto Purwada,
David Redmond,
Hao Shen,
Matt F. Challman,
Olivier Elemento,
Ankur Singh,
Ari M. Melnick

Affiliations

Wendy Béguelin: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University
Martín A. Rivas: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University
María T. Calvo Fernández: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University
Matt Teater: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University
Alberto Purwada: Meinig School of Biomedical Engineering, Cornell University
David Redmond: Institute for Computational Biomedicine, Weill Cornell Medicine, Cornell University
Hao Shen: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University
Matt F. Challman: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University
Olivier Elemento: Institute for Computational Biomedicine, Weill Cornell Medicine, Cornell University
Ankur Singh: Meinig School of Biomedical Engineering, Cornell University
Ari M. Melnick: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University

DOI: https://doi.org/10.1038/s41467-017-01029-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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