Nature Communications (Jan 2018)

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

  • Cornelis J. Korbee,
  • Matthias T. Heemskerk,
  • Dragi Kocev,
  • Elisabeth van Strijen,
  • Omid Rabiee,
  • Kees L. M. C. Franken,
  • Louis Wilson,
  • Nigel D. L. Savage,
  • Sašo Džeroski,
  • Mariëlle C. Haks,
  • Tom H. M. Ottenhoff

DOI
https://doi.org/10.1038/s41467-017-02777-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Multidrug resistance necessitates novel approaches to treating bacterial infections. Here, the authors apply their high-throughput screening and in silico prediction approaches to show that host receptor tyrosine kinases are good targets for host-directed therapies against intracellular bacteria.