Nature Communications (Jun 2022)
Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression
- Andrea Comba,
- Syed M. Faisal,
- Patrick J. Dunn,
- Anna E. Argento,
- Todd C. Hollon,
- Wajd N. Al-Holou,
- Maria Luisa Varela,
- Daniel B. Zamler,
- Gunnar L. Quass,
- Pierre F. Apostolides,
- Clifford Abel,
- Christine E. Brown,
- Phillip E. Kish,
- Alon Kahana,
- Celina G. Kleer,
- Sebastien Motsch,
- Maria G. Castro,
- Pedro R. Lowenstein
Affiliations
- Andrea Comba
- Department of Neurosurgery, University of Michigan Medical School
- Syed M. Faisal
- Department of Neurosurgery, University of Michigan Medical School
- Patrick J. Dunn
- Department of Neurosurgery, University of Michigan Medical School
- Anna E. Argento
- Department of Neurosurgery, University of Michigan Medical School
- Todd C. Hollon
- Department of Neurosurgery, University of Michigan Medical School
- Wajd N. Al-Holou
- Department of Neurosurgery, University of Michigan Medical School
- Maria Luisa Varela
- Department of Neurosurgery, University of Michigan Medical School
- Daniel B. Zamler
- Department of Neurosurgery, University of Michigan Medical School
- Gunnar L. Quass
- Kresge Hearing Research Institute, Department of Otolaryngology-Head & Neck Surgery, University of Michigan Medical School
- Pierre F. Apostolides
- Kresge Hearing Research Institute, Department of Otolaryngology-Head & Neck Surgery, University of Michigan Medical School
- Clifford Abel
- Department of Neurosurgery, University of Michigan Medical School
- Christine E. Brown
- Department of Hematology & Hematopoietic Cell Transplantation, National Medical Center, City of Hope
- Phillip E. Kish
- Department of Neurosurgery, University of Michigan Medical School
- Alon Kahana
- Ophthalmology & Visual Science, University of Michigan Medical School
- Celina G. Kleer
- Rogel Cancer Center, University of Michigan Medical School
- Sebastien Motsch
- School of Mathematical and Statistical Sciences, Arizona State University
- Maria G. Castro
- Department of Neurosurgery, University of Michigan Medical School
- Pedro R. Lowenstein
- Department of Neurosurgery, University of Michigan Medical School
- DOI
- https://doi.org/10.1038/s41467-022-31340-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
It is essential to improve our understanding of the features that influence aggressiveness and invasion in high grade gliomas (HGG). Here, the authors characterize dynamic anatomical structures in HGG called oncostreams, which are associated with tumor growth and are regulated by COL1A1.
