Nature Communications (Sep 2016)

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations

  • Annalisa Roberti,
  • Maria Pamela Dobay,
  • Bettina Bisig,
  • David Vallois,
  • Cloé Boéchat,
  • Evripidis Lanitis,
  • Brigitte Bouchindhomme,
  • Marie- Cécile Parrens,
  • Céline Bossard,
  • Leticia Quintanilla-Martinez,
  • Edoardo Missiaglia,
  • Philippe Gaulard,
  • Laurence de Leval

DOI
https://doi.org/10.1038/ncomms12602
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Enteropathy associated T-cell lymphoma -EATL- affects the intestine and there are two different subtypes. In this study, the authors carry out exome sequencing of the type II variant and find that it is characterized by recurrent mutations in the histone methyltransferase SETD2 that are accompanied by altered H3K6 methylation.