Nature Communications (Jan 2020)
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a
- Jinwei Zhang,
- Mohammad Iqbal H. Bhuiyan,
- Ting Zhang,
- Jason K. Karimy,
- Zhijuan Wu,
- Victoria M. Fiesler,
- Jingfang Zhang,
- Huachen Huang,
- Md Nabiul Hasan,
- Anna E. Skrzypiec,
- Mariusz Mucha,
- Daniel Duran,
- Wei Huang,
- Robert Pawlak,
- Lesley M. Foley,
- T. Kevin Hitchens,
- Margaret B. Minnigh,
- Samuel M. Poloyac,
- Seth L. Alper,
- Bradley J. Molyneaux,
- Andrew J. Trevelyan,
- Kristopher T. Kahle,
- Dandan Sun,
- Xianming Deng
Affiliations
- Jinwei Zhang
- Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories
- Mohammad Iqbal H. Bhuiyan
- Department of Neurology and Pittsburgh Institute For Neurodegenerative Diseases, University of Pittsburgh
- Ting Zhang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Jason K. Karimy
- Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology; Interdepartmental Neuroscience Program; and Centers for Mendelian Genomics, Yale School of Medicine
- Zhijuan Wu
- Newcastle University Business School, Newcastle University
- Victoria M. Fiesler
- Department of Neurology and Pittsburgh Institute For Neurodegenerative Diseases, University of Pittsburgh
- Jingfang Zhang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Huachen Huang
- Department of Neurology and Pittsburgh Institute For Neurodegenerative Diseases, University of Pittsburgh
- Md Nabiul Hasan
- Department of Neurology and Pittsburgh Institute For Neurodegenerative Diseases, University of Pittsburgh
- Anna E. Skrzypiec
- Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories
- Mariusz Mucha
- Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories
- Daniel Duran
- Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology; Interdepartmental Neuroscience Program; and Centers for Mendelian Genomics, Yale School of Medicine
- Wei Huang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Robert Pawlak
- Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories
- Lesley M. Foley
- Animal Imaging Center, University of Pittsburgh
- T. Kevin Hitchens
- Animal Imaging Center, University of Pittsburgh
- Margaret B. Minnigh
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh
- Samuel M. Poloyac
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh
- Seth L. Alper
- Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Bradley J. Molyneaux
- Department of Neurology and Pittsburgh Institute For Neurodegenerative Diseases, University of Pittsburgh
- Andrew J. Trevelyan
- Institute of Neuroscience, Medical School, Newcastle University, Framlington Place
- Kristopher T. Kahle
- Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology; Interdepartmental Neuroscience Program; and Centers for Mendelian Genomics, Yale School of Medicine
- Dandan Sun
- Department of Neurology and Pittsburgh Institute For Neurodegenerative Diseases, University of Pittsburgh
- Xianming Deng
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-019-13851-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.
