International Journal of COPD (Dec 2023)

Efficacy and Safety of Bisoprolol in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

  • Feng Z,
  • Zhang L,
  • Wang Y,
  • Guo H,
  • Liu J

Journal volume & issue
Vol. Volume 18
pp. 3067 – 3083

Abstract

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Zhouzhou Feng,1 Lu Zhang,1 Yaqin Wang,1 Hong Guo,1 Jian Liu1,2 1The First Clinical Medical College of Lanzhou University, Lanzhou City, People’s Republic of China; 2Gansu Maternal and Child Health Hospital/Gansu Central Hospital, Lanzhou City, People’s Republic of ChinaCorrespondence: Jian Liu, The First Clinical Medical College of Lanzhou University, Lanzhou City, 730000, People’s Republic of China, Tel +86 136 0935 4197, Email [email protected]: To evaluate the clinical efficacy and safety of bisoprolol in patients with chronic obstructive pulmonary disease (COPD).Research Methods: This systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statements. The primary outcome measures analyzed included: Pulmonary function(FEV1, FEV1%, FVC), 6-minute walking distance (6MWD), adverse events and inflammatory cytokines(IL-6, IL-8, CRP).Results: Thirty-five studies were included with a total of 3269 study participants, including 1650 in the bisoprolol group and 1619 in the control group. The effect of bisoprolol on lung function in patients with COPD, FEV1, MD (0.46 [95% CI, 0.27 to 0.65], P=0.000), FEV1%, MD (− 0.64 [95% CI, 0.42 to 0.86], P=0.000), FVC, MD (0.20 [95% CI, 0.05 to 0.34], P=0.008), the results all showed a statistically significant result. The effect of bisoprolol on 6MWD in COPD patients, MD (1.37 [95% CI, 1.08 to 1.66], P=0.000), which showed a statistically significant result. The occurrence of adverse events in COPD patients treated with bisoprolol, RR (0.83 [95% CI, 0.54 to 1.26], P=0.382), resulted in no statistical significance. The effect of bisoprolol on inflammatory cytokines in COPD patients, IL-6, MD (− 1.16 [95% CI, − 1.67 to − 0.65], P=0.000), IL-8, MD (− 0.94 [95% CI, − 1.32 to − 0.56], P=0.000), CRP, MD (− 1.74 [95% CI, − 2.40 to − 1.09], P=0.000), the results were statistically significant. We performed a subgroup analysis of each outcome indicator according to whether the patients had heart failure or not, and the results showed that the therapeutic effect of bisoprolol on COPD did not change with the presence or absence of heart failure.Conclusion: Bisoprolol is safe and effective in the treatment of COPD, improving lung function and exercise performance in patients with COPD, and also reducing inflammatory markers in patients with COPD, and this effect is independent of the presence or absence of heart failure.Keywords: chronic obstructive pulmonary disease, bisoprolol, beta-blockers, meta-analysis

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