Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

Changhai Lei; Kewen Qian; Tian Li; Sheng Zhang; Wenyan Fu; Min Ding; Shi Hu

doi:10.1038/s41467-020-16048-4

Nature Communications (Apr 2020)

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

Changhai Lei,
Kewen Qian,
Tian Li,
Sheng Zhang,
Wenyan Fu,
Min Ding,
Shi Hu

Affiliations

Changhai Lei: Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University
Kewen Qian: Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University
Tian Li: Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University
Sheng Zhang: Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Wenyan Fu: Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Min Ding: Pharchoice Therapeutics, Inc
Shi Hu: Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University

DOI: https://doi.org/10.1038/s41467-020-16048-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 5

Abstract

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SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of ACE2-Ig in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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