MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells

Amir Bahat; Andres Goldman; Yehudit Zaltsman; Dilshad H. Khan; Coral Halperin; Emmanuel Amzallag; Vladislav Krupalnik; Michael Mullokandov; Alon Silberman; Ayelet Erez; Aaron D. Schimmer; Jacob H. Hanna; Atan Gross

doi:10.1038/s41467-018-07519-w

Nature Communications (Dec 2018)

MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells

Amir Bahat,
Andres Goldman,
Yehudit Zaltsman,
Dilshad H. Khan,
Coral Halperin,
Emmanuel Amzallag,
Vladislav Krupalnik,
Michael Mullokandov,
Alon Silberman,
Ayelet Erez,
Aaron D. Schimmer,
Jacob H. Hanna,
Atan Gross

Affiliations

Amir Bahat: Department of Biological Regulation, Weizmann Institute of Science
Andres Goldman: Department of Biological Regulation, Weizmann Institute of Science
Yehudit Zaltsman: Department of Biological Regulation, Weizmann Institute of Science
Dilshad H. Khan: Princess Margaret Cancer Centre, University Health Network
Coral Halperin: Department of Biological Regulation, Weizmann Institute of Science
Emmanuel Amzallag: Department of Biological Regulation, Weizmann Institute of Science
Vladislav Krupalnik: Department of Molecular Genetics, Weizmann Institute of Science
Michael Mullokandov: Department of Biological Regulation, Weizmann Institute of Science
Alon Silberman: Department of Biological Regulation, Weizmann Institute of Science
Ayelet Erez: Department of Biological Regulation, Weizmann Institute of Science
Aaron D. Schimmer: Princess Margaret Cancer Centre, University Health Network
Jacob H. Hanna: Department of Molecular Genetics, Weizmann Institute of Science
Atan Gross: Department of Biological Regulation, Weizmann Institute of Science

DOI: https://doi.org/10.1038/s41467-018-07519-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Reprogramming of mitochondria metabolism occurs during naïve to primed pluripotency differentiation in mouse embryonic stem cells (ESCs). Here the authors show that mitochondrial MTCH2 regulates mitochondrial fusion and that this fusion is required for naïve to primed pluripotency conversion

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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