Port-site Metastasis from Gall Bladder Adenocarcinoma with Squamous Differentiation Following Laparoscopic Cholecystectomy: A Rare Case Report

Abstract

Port site cutaneous metastasis of gallbladder cancer is an exceedingly infrequent phenomenon with very few cases reported in the past. Herein, we report a case of port site cutaneous metastases of gallbladder adenocarcinoma in a 57 years old female. Physical examination revealed a non healing ulcer in the epigastric region. FNA was suggestive of poorly differentiated carcinoma. Biopsy demonstrated atypical cells. Immunohistochemical analysis showed diffuse cytoplasmic staining with CK 7 and p63 showed focal nuclear positivity in tumour cells. This confirmed the diagnosis of metastastatic gall bladder adenocarcinoma with squamous differentiation. Diagnosis in such a case can be very challenging as the differential of primary cutaneous malignancies should also be kept in mind.

Keywords

• adenocarcinoma, gallbladder, immunohistochemistry, metastases, port site.