Nature Communications (Sep 2019)

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

  • Yuhong Chen,
  • Mei Yu,
  • Yongwei Zheng,
  • Guoping Fu,
  • Gang Xin,
  • Wen Zhu,
  • Lan Luo,
  • Robert Burns,
  • Quan-Zhen Li,
  • Alexander L. Dent,
  • Nan Zhu,
  • Weiguo Cui,
  • Laurent Malherbe,
  • Renren Wen,
  • Demin Wang

DOI
https://doi.org/10.1038/s41467-019-12446-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and induces concomitant production of autoantibodies.