YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation

Nattaya Damkham; Chanchao Lorthongpanich; Phatchanat Klaihmon; Usaneeporn Lueangamornnara; Pakpoom Kheolamai; Kongtana Trakarnsanga; Surapol Issaragrisil

doi:10.1186/s13287-022-03166-7

Stem Cell Research & Therapy (Sep 2022)

YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation

Nattaya Damkham,
Chanchao Lorthongpanich,
Phatchanat Klaihmon,
Usaneeporn Lueangamornnara,
Pakpoom Kheolamai,
Kongtana Trakarnsanga,
Surapol Issaragrisil

Affiliations

Nattaya Damkham: Graduate Program in Immunology, Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University
Chanchao Lorthongpanich: Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University
Phatchanat Klaihmon: Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University
Usaneeporn Lueangamornnara: Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Pakpoom Kheolamai: Division of Cell Biology, Department of Pre-Clinical Science, Faculty of Medicine, Thammasat University
Kongtana Trakarnsanga: Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University
Surapol Issaragrisil: Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University

DOI: https://doi.org/10.1186/s13287-022-03166-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Key point YAP and TAZ are required for erythroid maturation and enucleation, but they are dispensable during human HSC lineage allocation to myeloid or erythroid lineages.

Published in Stem Cell Research & Therapy

ISSN: 1757-6512 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General); Science: Chemistry: Organic chemistry: Biochemistry
Website: https://stemcellres.biomedcentral.com

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Abstract

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