IJTLD Open (May 2025)

Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB

  • C. Zeng,
  • M.A. Hernán,
  • L. Trevisi,
  • S. Sauer,
  • C.D. Mitnick,
  • C. Hewison,
  • M. Bastard,
  • P. Khan,
  • K.J. Seung,
  • M.L. Rich,
  • S. Law,
  • M. Kikvidze,
  • O. Kirakosyan,
  • A. Miankou,
  • P. Thit,
  • S. Mamsa,
  • A. Janmohamed,
  • N. Melikyan,
  • S. Ahmed,
  • D. Vargas,
  • A.B. Binegdie,
  • K. Temirova,
  • L. Oyewusi,
  • K. Philippe,
  • S.C. Vilbrun,
  • U. Khan,
  • H. Huerga,
  • M.F. Franke,
  • on behalf of the endTB Observational Study Team

DOI
https://doi.org/10.5588/ijtldopen.24.0515
Journal volume & issue
Vol. 2, no. 5
pp. 269 – 275

Abstract

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INTRODUCTION: Costs for nutritional supplements and food were the main driver of costs incurred by TB-affected households in Lao People’s Democratic Republic. This study assessed the impact of nutritional counselling and support on costs incurred by TB-affected households. METHODS: We conducted longitudinal data collection of costs, income, and coping mechanisms of TB-affected households within an intervention study providing nutritional counselling and support for people diagnosed with TB and having a body mass index (BMI) <18.5 kg/m2. Data collection tools were adapted from the WHO’s generic national TB patient cost survey questionnaire to fit a longitudinal study design. Costs were considered catastrophic when they exceeded 20% of annual household income before TB. RESULTS: A total of 268 people treated for drug-susceptible TB were included in the analysis, and the prevalence of BMI <18.5 kg/m2 was 38%. The intervention group had significantly lower nutritional supplement costs and direct non-medical costs after TB diagnosis than the observation group. The intervention group had less progressive catastrophic costs (+23.3 percentage points) than the observation group (+30.9 percentage points). CONCLUSION: Nutritional counselling and support were significantly associated with a reduction in the proportion of TB-affected households facing catastrophic costs due to TB.

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