Nature Communications (Dec 2020)
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
- Johanna Grinat,
- Julian Heuberger,
- Ramon Oliveira Vidal,
- Neha Goveas,
- Frauke Kosel,
- Antoni Berenguer-Llergo,
- Andrea Kranz,
- Annika Wulf-Goldenberg,
- Diana Behrens,
- Bálint Melcher,
- Sascha Sauer,
- Michael Vieth,
- Eduard Batlle,
- A. Francis Stewart,
- Walter Birchmeier
Affiliations
- Johanna Grinat
- Cancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society
- Julian Heuberger
- Cancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society
- Ramon Oliveira Vidal
- Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH)
- Neha Goveas
- Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden
- Frauke Kosel
- Cancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society
- Antoni Berenguer-Llergo
- Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Andrea Kranz
- Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden
- Annika Wulf-Goldenberg
- Experimental Pharmacology & Oncology (EPO)
- Diana Behrens
- Experimental Pharmacology & Oncology (EPO)
- Bálint Melcher
- Institute for Pathology, Klinikum Bayreuth
- Sascha Sauer
- Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH)
- Michael Vieth
- Institute for Pathology, Klinikum Bayreuth
- Eduard Batlle
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- A. Francis Stewart
- Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden
- Walter Birchmeier
- Cancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society
- DOI
- https://doi.org/10.1038/s41467-020-20222-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.
