Nature Communications (Apr 2016)

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

  • Michael J. Lukey,
  • Kai Su Greene,
  • Jon W. Erickson,
  • Kristin F. Wilson,
  • Richard A. Cerione

DOI
https://doi.org/10.1038/ncomms11321
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer sensitivity to glutaminase-targeted therapy.