Synthesis of the pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4

Abstract

The pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4 strain has been synthesized using a combination of sequential glycosylations and [3 + 2] block synthetic strategy from the suitably protected monosaccharide intermediates. Thioglycosides and glycosyl trichloroacetimidate derivatives have been used as glycosyl donors in the glycosylations.

Keywords

• Escherichia coli
• glycosylation
• lipopolysaccharide
• O-antigen
• pentasaccharide