Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

Abstract

The basal nucleus of Meynert (NBM) plays a role in cognition by modulating cortical circuits. Here, the authors demonstrate plasticity of the NBM upon tissue injury, and that activating NBM cholinergic-GABAergic projections to the prefrontal cortex alleviates chronic pain-like behaviour in mice.