Global climate change is anticipated to have a profound impact on drought occurrences, leading to detrimental consequences for the environment, socioeconomic relations, and ecosystem services. In order to evaluate the extent of drought impact, a comprehensive study was conducted in the Hyderabad–Karnataka region, India. Precipitation data from 31 stations spanning a 50-year period (1967–2017) were analyzed using the standardized precipitation index (SPI) based on gamma distribution. The findings reveal that approximately 15% of the assessed years of experienced drought conditions, with a range of influence between 41% and 76% under SPI_3, and between 43% and 72% under SPI_6. Examining the timescale magnitude frequency provided insights into variations in the severity of drought events across different locations and timescales. Notably, the Ballari (−8.77), Chitapur (−8.22), and Aland (−7.40) regions exhibited the most significant magnitudes of drought events for SPI_3 with a 5-year return period. The heightened risk of recurrent droughts in the study area emphasizes the necessity of integrating SPI in decision-making processes, as such integration can markedly contribute to the development of reliable and sustainable long-term water management strategies at regional and national levels.