Resistance Exercise Program: Intervention To Reduce Inflammation And Improve Nutritional Status In Hemodialysis Patients

Abstract

Exercise programs have been recommended as nutritional interventions in hemodialysis (HD) patients to minimize loss of muscle mass, improve physical and functional capacity, inflammation thus controlling or preventing cardiovascular diseases (CVD), which accounts for 50% of mortality in dialysis patients. Therefore the purpose of this study was to analyze the effects of a resistance exercise (RE) program on biochemical parameters, inflammation markers, and body composition in HD patients. Thirty- six HD patients (61.1% men, mean age 46.7±2.5yrs) were studied. The anthropometric and biochemical parameters are presented in Table. There were significant differences after 6 months of RE in albumin and CRP plasma levels and body composition parameters. The HD patients gained nearly 3kg of lean mass and lost about 3% of body fat. Parameters Before(n=30) After(n=30) BMI (kg/m2) 22.8±4.0 23.3±4.3 Arm muscular area (cm) 30.3±13.7 35.4±13.8* Body Fat (%) 31.5±5.6 28.4±5.9* Lean mass (kg) 42.4±10.0 45.5±11.0* Albumin (g/dL) 3.6±0.3 3.8±0.2* Globulin (g/dL) 3.2±0.3 2.8±0.5** Interleukin-6 (pg/mL) 81.3±9.4 78.7±10.4 TNF-α (pg/mL) 25.7±6.5 24.3±8.7 Creatinine (mg/dL) 12.5±3.6 12.2±3.7 CRP (pg/mL) 2.9±0.4 2.0±0.1* ⁎ p<001. ⁎⁎ p<05. In conclusion, statistically significant improvements were observed in body composition, albumin and CRP levels after 6 months of resistance exercises. Therefore, RE provide better prognosis in HD patients reducing cardiovascular risk, inflammation and loss of muscle mass.