Nature Communications (May 2022)
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis
- Yun Zhang,
- Shuaijun Li,
- Peisheng Jin,
- Ting Shang,
- Ruizhu Sun,
- Laiya Lu,
- Kaijin Guo,
- Jiping Liu,
- Yongjuan Tong,
- Junbang Wang,
- Sanhong Liu,
- Chen Wang,
- Yubin Kang,
- Wenmin Zhu,
- Qian Wang,
- Xiaoren Zhang,
- Feng Yin,
- Yi Eve Sun,
- Lei Cui
Affiliations
- Yun Zhang
- Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine
- Shuaijun Li
- Key Laboratory of spine and spinal cord injury repair and regeneration, Ministry of Education of the People’s Republic of China & Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine
- Peisheng Jin
- Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University
- Ting Shang
- Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University
- Ruizhu Sun
- Key Laboratory of spine and spinal cord injury repair and regeneration, Ministry of Education of the People’s Republic of China & Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine
- Laiya Lu
- Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine
- Kaijin Guo
- Department of Orthopedics, Affiliated Hospital of Xuzhou Medical University
- Jiping Liu
- Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine
- Yongjuan Tong
- Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University
- Junbang Wang
- Translational Stem Cell Research Center, Tongji Hospital, Tongji University School of Medicine
- Sanhong Liu
- Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
- Chen Wang
- Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
- Yubin Kang
- Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University
- Wenmin Zhu
- Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine
- Qian Wang
- Key Laboratory of spine and spinal cord injury repair and regeneration, Ministry of Education of the People’s Republic of China & Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine
- Xiaoren Zhang
- Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, Affiliated Cancer Hospital & Institute of Guangzhou Medical University
- Feng Yin
- Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine
- Yi Eve Sun
- Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine
- Lei Cui
- Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-30119-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Osteoarthritic (OA) is characterized by progressive destruction of joint cartilage. Here, the authors show that microRNA-17 plays a dual role in maintaining cartilage homeostasis and in the prevention of osteoarthritis, by targeting hypoxia-inducible factor-1α as well as multiple matrix-degrading enzymes.
