Nature Communications (Apr 2022)
PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity
- Caroline Hoffmann,
- Floriane Noel,
- Maximilien Grandclaudon,
- Lucile Massenet-Regad,
- Paula Michea,
- Philemon Sirven,
- Lilith Faucheux,
- Aurore Surun,
- Olivier Lantz,
- Mylene Bohec,
- Jian Ye,
- Weihua Guo,
- Juliette Rochefort,
- Jerzy Klijanienko,
- Sylvain Baulande,
- Charlotte Lecerf,
- Maud Kamal,
- Christophe Le Tourneau,
- Maude Guillot-Delost,
- Vassili Soumelis
Affiliations
- Caroline Hoffmann
- Institut Curie, INSERM U932, Immunity and Cancer
- Floriane Noel
- Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis
- Maximilien Grandclaudon
- Institut Curie, INSERM U932, Immunity and Cancer
- Lucile Massenet-Regad
- Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis
- Paula Michea
- Institut Paoli Calmette, INSERM U1068—CNRS UMR7258—AMU UM105
- Philemon Sirven
- Institut Curie, INSERM U932, Immunity and Cancer
- Lilith Faucheux
- Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis
- Aurore Surun
- Institut Curie, SIREDO Cancer Center
- Olivier Lantz
- Institut Curie, INSERM U932, Immunity and Cancer
- Mylene Bohec
- Université Paris Sciences Lettres (PSL)
- Jian Ye
- City of Hope Comprehensive Cancer Center, Department of Immuno-Oncology
- Weihua Guo
- City of Hope Comprehensive Cancer Center, Department of Immuno-Oncology
- Juliette Rochefort
- Cimi Paris, INSERM U1135, and Hospital Pitié Salpêtrière, Odontology department, Université de Paris
- Jerzy Klijanienko
- Université Paris Sciences Lettres (PSL)
- Sylvain Baulande
- Université Paris Sciences Lettres (PSL)
- Charlotte Lecerf
- Université Paris Sciences Lettres (PSL)
- Maud Kamal
- Université Paris Sciences Lettres (PSL)
- Christophe Le Tourneau
- Université Paris-Saclay
- Maude Guillot-Delost
- Institut Curie, INSERM U932, Immunity and Cancer
- Vassili Soumelis
- Institut Curie, INSERM U932, Immunity and Cancer
- DOI
- https://doi.org/10.1038/s41467-022-29516-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Phenotypic and functional states of dendritic cells critically influence the outcome of cancer and inflammation. Authors here show by single cell transcriptomics and in vitro validation assays that dichotomous PD-L1 and ICOSL expression assign dendritic cells to secretory and helper functions, with respective predominance of inflammatory cytokine expression or T helper cytokine induction.
