Stereo selective synthesis of C3–C12 fragment of iriomoteolide-1a

Abstract

A convergent and flexible synthetic route for the synthesis of C3–C12 fragment of iriomoteolide-1a is described. The key steps are: Mannich reaction, Keck asymmetric allylation, Sharpless asymmetric epoxidation and cross-metathesis protocol.

Keywords

• Iriomoteolide-1a
• Mannich reaction
• Sharpless epoxidation
• Keck allylation
• Cross-metathesis