Communications Biology (Mar 2023)
DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice
- Laura Senatus,
- Lander Egaña-Gorroño,
- Raquel López-Díez,
- Sonia Bergaya,
- Juan Francisco Aranda,
- Jaume Amengual,
- Lakshmi Arivazhagan,
- Michaele B. Manigrasso,
- Gautham Yepuri,
- Ramesh Nimma,
- Kaamashri N. Mangar,
- Rollanda Bernadin,
- Boyan Zhou,
- Paul F. Gugger,
- Huilin Li,
- Richard A. Friedman,
- Neil D. Theise,
- Alexander Shekhtman,
- Edward A. Fisher,
- Ravichandran Ramasamy,
- Ann Marie Schmidt
Affiliations
- Laura Senatus
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Lander Egaña-Gorroño
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Raquel López-Díez
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Sonia Bergaya
- The Leon H. Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, NYU Grossman School of Medicine, NYU Langone Health
- Juan Francisco Aranda
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Jaume Amengual
- The Leon H. Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, NYU Grossman School of Medicine, NYU Langone Health
- Lakshmi Arivazhagan
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Michaele B. Manigrasso
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Gautham Yepuri
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Ramesh Nimma
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Kaamashri N. Mangar
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Rollanda Bernadin
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Boyan Zhou
- Department of Population Health, Division of Biostatistics, NYU Grossman School of Medicine, NYU Langone Health
- Paul F. Gugger
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Huilin Li
- Department of Population Health, Division of Biostatistics, NYU Grossman School of Medicine, NYU Langone Health
- Richard A. Friedman
- Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center and Department of Biomedical Informatics, Columbia University Irving Medical Center
- Neil D. Theise
- Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health
- Alexander Shekhtman
- Department of Chemistry, The State University of New York at Albany
- Edward A. Fisher
- The Leon H. Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, NYU Grossman School of Medicine, NYU Langone Health
- Ravichandran Ramasamy
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- Ann Marie Schmidt
- Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health
- DOI
- https://doi.org/10.1038/s42003-023-04643-2
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 20
Abstract
Male and female mice deficient in DIAPH1 are protected from the development of experimental atherosclerosis and display reduced cholesterol levels; these changes are linked to the regulation of SREBP1 subcellular localization.
