Nature Communications (Feb 2016)
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology
- Eric A. Hungate,
- Sapana R. Vora,
- Eric R. Gamazon,
- Takaya Moriyama,
- Timothy Best,
- Imge Hulur,
- Younghee Lee,
- Tiffany-Jane Evans,
- Eva Ellinghaus,
- Martin Stanulla,
- Jéremie Rudant,
- Laurent Orsi,
- Jacqueline Clavel,
- Elizabeth Milne,
- Rodney J. Scott,
- Ching-Hon Pui,
- Nancy J. Cox,
- Mignon L. Loh,
- Jun J. Yang,
- Andrew D. Skol,
- Kenan Onel
Affiliations
- Eric A. Hungate
- Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA
- Sapana R. Vora
- Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA
- Eric R. Gamazon
- Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
- Takaya Moriyama
- Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
- Timothy Best
- Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA
- Imge Hulur
- Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60637, USA
- Younghee Lee
- Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
- Tiffany-Jane Evans
- Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305, Australia
- Eva Ellinghaus
- Institute of Clinical Molecular Biology, Christian-Albrechts University
- Martin Stanulla
- Department of Pediatrics, University Hospital Schleswig-Holstein
- Jéremie Rudant
- INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA)
- Laurent Orsi
- INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA)
- Jacqueline Clavel
- INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA)
- Elizabeth Milne
- Telethon Kids Institute, University of Western Australia
- Rodney J. Scott
- Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305, Australia
- Ching-Hon Pui
- Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
- Nancy J. Cox
- Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
- Mignon L. Loh
- Department of Pediatrics, University of California–San Francisco, San Francisco, California 94143, USA
- Jun J. Yang
- Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
- Andrew D. Skol
- Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA
- Kenan Onel
- Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA
- DOI
- https://doi.org/10.1038/ncomms10635
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b.
