Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster

Yang Lyu; Daniel E. L. Promislow; Scott D. Pletcher

doi:10.1038/s42003-021-02260-5

Communications Biology (Jun 2021)

Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster

Yang Lyu,
Daniel E. L. Promislow,
Scott D. Pletcher

Affiliations

Yang Lyu: Department of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan
Daniel E. L. Promislow: Department of Lab Medicine and Pathology, University of Washington School of Medicine
Scott D. Pletcher: Department of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan

DOI: https://doi.org/10.1038/s42003-021-02260-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Lyu et al analysed metabolic network integrity in Drosophila melanogaster to assess the systemic effects of nutrient choice. By knocking out the serotonin receptor, 5-HT2A, they demonstrated that the effects of different macronutrients on the stability of metabolic networks is mediated through serotonin signalling.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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