Nature Communications (Sep 2017)

APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

  • Ting-Wen Chen,
  • Chi-Ching Lee,
  • Hsuan Liu,
  • Chi-Sheng Wu,
  • Curtis R. Pickering,
  • Po-Jung Huang,
  • Jing Wang,
  • Ian Yi-Feng Chang,
  • Yuan-Ming Yeh,
  • Chih-De Chen,
  • Hsin-Pai Li,
  • Ji-Dung Luo,
  • Bertrand Chin-Ming Tan,
  • Timothy En Haw Chan,
  • Chuen Hsueh,
  • Lichieh Julie Chu,
  • Yi-Ting Chen,
  • Bing Zhang,
  • Chia-Yu Yang,
  • Chih-Ching Wu,
  • Chia-Wei Hsu,
  • Lai-Chu See,
  • Petrus Tang,
  • Jau-Song Yu,
  • Wei-Chao Liao,
  • Wei-Fan Chiang,
  • Henry Rodriguez,
  • Jeffrey N. Myers,
  • Kai-Ping Chang,
  • Yu-Sun Chang

DOI
https://doi.org/10.1038/s41467-017-00493-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Oral squamous cell carcinoma is a prevalent malignancy in Taiwan. Here, the authors show that OSCC in Taiwanese show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression of A3A, which is shown to be of clinical prognostic relevance.