Nature Communications (May 2022)
Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers
- N. Shukla,
- M. F. Levine,
- G. Gundem,
- D. Domenico,
- B. Spitzer,
- N. Bouvier,
- J. E. Arango-Ossa,
- D. Glodzik,
- J. S. Medina-Martínez,
- U. Bhanot,
- J. Gutiérrez-Abril,
- Y. Zhou,
- E. Fiala,
- E. Stockfisch,
- S. Li,
- M. I. Rodriguez-Sanchez,
- T. O’Donohue,
- C. Cobbs,
- M. H. A. Roehrl,
- J. Benhamida,
- F. Iglesias Cardenas,
- M. Ortiz,
- M. Kinnaman,
- S. Roberts,
- M. Ladanyi,
- S. Modak,
- S. Farouk-Sait,
- E. Slotkin,
- M. A. Karajannis,
- F. Dela Cruz,
- J. Glade Bender,
- A. Zehir,
- A. Viale,
- M. F. Walsh,
- A. L. Kung,
- E. Papaemmanuil
Affiliations
- N. Shukla
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- M. F. Levine
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- G. Gundem
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- D. Domenico
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- B. Spitzer
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- N. Bouvier
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- J. E. Arango-Ossa
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- D. Glodzik
- Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center
- J. S. Medina-Martínez
- Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center
- U. Bhanot
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- J. Gutiérrez-Abril
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Y. Zhou
- Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center
- E. Fiala
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- E. Stockfisch
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- S. Li
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- M. I. Rodriguez-Sanchez
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- T. O’Donohue
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- C. Cobbs
- Integrated Genomics Operation Core, Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- M. H. A. Roehrl
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- J. Benhamida
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- F. Iglesias Cardenas
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- M. Ortiz
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- M. Kinnaman
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- S. Roberts
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- M. Ladanyi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- S. Modak
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- S. Farouk-Sait
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- E. Slotkin
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- M. A. Karajannis
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- F. Dela Cruz
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- J. Glade Bender
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- A. Zehir
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- A. Viale
- Integrated Genomics Operation Core, Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- M. F. Walsh
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- A. L. Kung
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- E. Papaemmanuil
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-30233-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Cancer whole-genome and transcriptome sequencing (cWGTS) has been challenging to implement in clinical settings. Here, the authors develop a workflow to deliver robust cWGTS analyses and reports within clinically-relevant timeframes for paediatric, adolescent and young adult solid tumour patients.
