Comparison of Solid and Solvent - Based Syntheses, Characterization and Antioxidant Property of Metal Complexes of Sodium Diclofenac

W. A. Osunniran; Y. O. Ayipo; M. A. Adeyemo; A.T. Bale; J. A. Obaleye

Fountain Journal of Natural and Applied Sciences (FUJNAS) (Aug 2020)

Comparison of Solid and Solvent - Based Syntheses, Characterization and Antioxidant Property of Metal Complexes of Sodium Diclofenac

W. A. Osunniran,
Y. O. Ayipo,
M. A. Adeyemo,
A.T. Bale,
J. A. Obaleye

Affiliations

W. A. Osunniran: Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Ilorin, Nigeria.
Y. O. Ayipo: Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Ilorin, Nigeria.
M. A. Adeyemo: Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Ilorin, Nigeria.
A.T. Bale: Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Ilorin, Nigeria.
J. A. Obaleye: Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria

Journal volume & issue: Vol. 9, no. 1

Abstract

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Mechanosynthesis and solvent – based syntheses of transition metals (Ni, Co and Zn) complexes of Sodium diclofenac has been carried out by 1:1 molar ratio of the ligand to metal salts respectively. The synthesis of the metal complexes were confirmed by melting point determination, FT-IR (Fourier Transform Infra-red) and UV-visible spectroscopies. The ligand showed bidentate coordination to the metal ions through carboxylate moiety. Octahedral geometry was proposed for all the metal complexes. The antioxidant property of metal complexes was determined using DPPH (1,1-diphenyl-2-picrylhydrazyl) assay with Ascorbic acid as control. The antioxidant evaluation results revealed that the synthesized metal complexes are promising antioxidant agents. Keywords: Mechanosynthesis; DPPH; Carboxylate moiety; antioxidant evaluation

Published in Fountain Journal of Natural and Applied Sciences (FUJNAS)

ISSN: 2350-1863 (Print); 2354-337X (Online)
Publisher: Fountain University Osogbo
Country of publisher: Nigeria
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences; Science: Physics; Science: Biology (General); Technology: Chemical technology: Chemical engineering; Agriculture: Agriculture (General)
Website: https://fountainjournals.com/index.php/FUJNAS/index

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