Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Ya Cui; Frederick J. Arnold; Fanglue Peng; Dan Wang; Jason Sheng Li; Sebastian Michels; Eric J. Wagner; Albert R. La Spada; Wei Li

doi:10.1038/s41467-023-36311-8

Nature Communications (Feb 2023)

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Ya Cui,
Frederick J. Arnold,
Fanglue Peng,
Dan Wang,
Jason Sheng Li,
Sebastian Michels,
Eric J. Wagner,
Albert R. La Spada,
Wei Li

Affiliations

Ya Cui: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine
Frederick J. Arnold: Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, School of Medicine, and the UCI Institute for Neurotherapeutics, University of California Irvine
Fanglue Peng: Department of Molecular and Cellular Biology, University Baylor College of Medicine
Dan Wang: Department of Medicine, Division of Cardiology, University of California, Los Angeles
Jason Sheng Li: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine
Sebastian Michels: Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, School of Medicine, and the UCI Institute for Neurotherapeutics, University of California Irvine
Eric J. Wagner: School of Medicine and Dentistry, University of Rochester Medical Center
Albert R. La Spada: Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, School of Medicine, and the UCI Institute for Neurotherapeutics, University of California Irvine
Wei Li: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine

DOI: https://doi.org/10.1038/s41467-023-36311-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

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Alternative polyadenylation (APA) contributes to the post-transcriptional regulation of most human genes, yet the effects of APA are largely overlooked by conventional transcriptome-wide association studies (TWAS). Here, the authors conduct an APA-TWAS for 11 brain disorders, identifying hundreds of APA-linked disease susceptibility genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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