Nature Communications (Dec 2017)
Rhythmic potassium transport regulates the circadian clock in human red blood cells
- Erin A. Henslee,
- Priya Crosby,
- Stephen J. Kitcatt,
- Jack S. W. Parry,
- Andrea Bernardini,
- Rula G. Abdallat,
- Gabriella Braun,
- Henry O. Fatoyinbo,
- Esther J. Harrison,
- Rachel S. Edgar,
- Kai F. Hoettges,
- Akhilesh B. Reddy,
- Rita I. Jabr,
- Malcolm von Schantz,
- John S. O’Neill,
- Fatima H. Labeed
Affiliations
- Erin A. Henslee
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Priya Crosby
- MRC Laboratory of Molecular Biology
- Stephen J. Kitcatt
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Jack S. W. Parry
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Andrea Bernardini
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Rula G. Abdallat
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Gabriella Braun
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Henry O. Fatoyinbo
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Esther J. Harrison
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Rachel S. Edgar
- MRC Laboratory of Molecular Biology
- Kai F. Hoettges
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- Akhilesh B. Reddy
- The Francis Crick Institute
- Rita I. Jabr
- Faculty of Health and Medical Sciences, University of Surrey
- Malcolm von Schantz
- Faculty of Health and Medical Sciences, University of Surrey
- John S. O’Neill
- MRC Laboratory of Molecular Biology
- Fatima H. Labeed
- Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey
- DOI
- https://doi.org/10.1038/s41467-017-02161-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Circadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA. Here, Henslee and colleagues show that circadian rhythms in isolated human red blood cells are dependent on rhythmic transport of K+ ions.
