Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

• Yinghui Wei,
• Chunlong Xu,
• Hu Feng,
• Kui Xu,
• Zhifang Li,
• Jing Hu,
• Ling Zhou,
• Yu Wei,
• Zhenrui Zuo,
• Erwei Zuo,
• Wen Li,
• Hui Yang,
• Meiling Zhang

Affiliations

Yinghui Wei

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University

Chunlong Xu

Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology

Hu Feng

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences

Kui Xu

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences

Zhifang Li

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences

Jing Hu

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Ling Zhou

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences

Yu Wei

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Zhenrui Zuo

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences

Erwei Zuo

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences

Wen Li

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University

Hui Yang

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Meiling Zhang

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University