The role of haematological parameters in predicting the response to radical chemoradiotherapy in patients with anal squamous cell cancer

Abstract

Historically, the treatment of choice for anal cancer had been abdominoperineal resection (APR). Radical radiotherapy with concurrent 5-fluorouracil plus mitomycin C chemotherapy was later established as standard therapy, although with a failure rate of 20–30%. The aim of this study was to evaluate the outcomes after radical chemoradiotherapy (CRT), prognostic and predictive factors and patterns of failure.

Keywords

• anal cancer
• chemoradiotherapy
• haematological parameters