Nature Communications (Apr 2019)
A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
- Alexander D. Douglas,
- G. Christian Baldeviano,
- Jing Jin,
- Kazutoyo Miura,
- Ababacar Diouf,
- Zenon A. Zenonos,
- Julio A. Ventocilla,
- Sarah E. Silk,
- Jennifer M. Marshall,
- Daniel G. W. Alanine,
- Chuan Wang,
- Nick J. Edwards,
- Karina P. Leiva,
- Luis A. Gomez-Puerta,
- Carmen M. Lucas,
- Gavin J. Wright,
- Carole A. Long,
- Joseph M. Royal,
- Simon J. Draper
Affiliations
- Alexander D. Douglas
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- G. Christian Baldeviano
- US Naval Medical Research Unit No. 6 (NAMRU-6)
- Jing Jin
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- Kazutoyo Miura
- Laboratory of Malaria and Vector Research, NIAID/NIH
- Ababacar Diouf
- Laboratory of Malaria and Vector Research, NIAID/NIH
- Zenon A. Zenonos
- Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute
- Julio A. Ventocilla
- US Naval Medical Research Unit No. 6 (NAMRU-6)
- Sarah E. Silk
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- Jennifer M. Marshall
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- Daniel G. W. Alanine
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- Chuan Wang
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- Nick J. Edwards
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- Karina P. Leiva
- US Naval Medical Research Unit No. 6 (NAMRU-6)
- Luis A. Gomez-Puerta
- US Naval Medical Research Unit No. 6 (NAMRU-6)
- Carmen M. Lucas
- US Naval Medical Research Unit No. 6 (NAMRU-6)
- Gavin J. Wright
- Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute
- Carole A. Long
- Laboratory of Malaria and Vector Research, NIAID/NIH
- Joseph M. Royal
- US Naval Medical Research Unit No. 6 (NAMRU-6)
- Simon J. Draper
- Jenner Institute, University of Oxford, Old Road Campus Research Building
- DOI
- https://doi.org/10.1038/s41467-019-09894-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 8
Abstract
Proof of protection against blood-stage P. falciparum malaria by a single immunological mechanism has been elusive. Here, using engineered anti-PfRH5 chimeric monoclonal antibodies in non-human primates, the authors show that high levels of merozoite-neutralizing antibodies can achieve protection.
