Nature Communications (Feb 2023)

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity

  • Liang Yang,
  • Junfeng Shen,
  • Chunhua Liu,
  • Zhonghua Kuang,
  • Yong Tang,
  • Zhengjiang Qian,
  • Min Guan,
  • Yongfeng Yang,
  • Yang Zhan,
  • Nan Li,
  • Xiang Li

DOI
https://doi.org/10.1038/s41467-023-36543-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 17

Abstract

Read online

Nicotine, a metabolite of the NAD+ metabolic pathway, has been found to possess anti-inflammatory and neuroprotective properties, yet the underlying molecular mechanisms remained unknown. Here, the authors show that low-dose nicotine promotes SIRT1 deacetylation of NAMPT and enhanced NAMPT activity which boosts NAD generation and improves age related symptoms.